A Miss. baby born with HIV and hoped to have been cured by aggressive drugs started right after birth now shows signs of infection. Dr. Anthony Fauci of the NIH says the nearly 4-year-old girl is responding well to renewed treatment. (July 10)
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A Miss. baby born with HIV and hoped to have been cured by aggressive drugs started right after birth now shows signs of infection. Dr. Anthony Fauci of the NIH says the nearly 4-year-old girl is responding well to renewed treatment. (July 10)
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A baby born with the virus that causes AIDS appears to have been cured, scientists announced Sunday, describing the case of a child from Mississippi who's now 2½ and has been off medication for about a year with no signs of infection.
There's no guarantee the child will remain healthy, although sophisticated testing uncovered just traces of the virus' genetic material still lingering. If so, it would mark only the world's second reported cure.
Specialists say Sunday's announcement, at a major AIDS meeting in Atlanta, offers promising clues for efforts to eliminate HIV infection in children, especially in AIDS-plagued African countries where too many babies are born with the virus.
'You could call this about as close to a cure, if not a cure, that we've seen,' Dr. Anthony Fauci of the National Institutes of Health, who is familiar with the findings, told The Associated Press.
A doctor gave this baby faster and stronger treatment than is usual, starting a three-drug infusion within 30 hours of birth. That was before tests confirmed the infant was infected and not just at risk from a mother whose HIV wasn't diagnosed until she was in labor.
'I just felt like this baby was at higher-than-normal risk, and deserved our best shot,' Dr. Hannah Gay, a pediatric HIV specialist at the University of Mississippi, said in an interview.
That fast a
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A Mississippi baby born with the AIDS virus appears to have been cured after being treated with an aggressive regimen of drugs just after her birth 2½ years ago, an unusual case that could trigger changes in care for hundreds of thousands of babies born globally each year with HIV.
The findings, reported Sunday by researchers, mark only the second documented case of a patient being cured of infection with the human immune-deficiency virus. The first, an adult man known as the Berlin patient, was cured as a result of a 2007 bone-marrow transplant.
The new case was discovered after the baby girl's mother stopped treatment on her, and doctors realized that the virus was undetectable even without drugs, which HIV patients normally must take for the rest of their lives.
Researchers cautioned that the report on the baby girl involves just one patient, and the findings appear to have little immediate relevance to people who contract HIV as adults or adolescents and are almost always diagnosed and treated long after their initial infection. But if further study confirms that very early treatment can cure HIV-infected newborns, it could spur widespread use of such an aggressive regimen in babies born with HIV, nearly all of them in low- and middle-income countries.
World Health Organization guidelines now call for treating infants born to an HIV-infected mother with a modest daily dose of antiretroviral treatment for four to six
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A baby girl in Mississippi who was born with HIV has been cured after very early treatment with standard HIV drugs, U.S. researchers reported on Sunday, in a potentially ground-breaking case that could offer insights on how to eradicate HIV infection in its youngest victims.
The child's story is the first account of an infant achieving a so-called functional cure, a rare event in which a person achieves remission without the need for drugs and standard blood tests show no signs that the virus is making copies of itself.
More testing needs to be done to see if the treatment would have the same effect on other children, but the results could change the way high-risk babies are treated and possibly lead to a cure for children with HIV, the virus that causes AIDS.
'This is a proof of concept that HIV can be potentially curable in infants,' said Dr. Deborah Persaud, a virologist at Johns Hopkins University in Baltimore, who presented the findings at the Conference on Retroviruses and Opportunistic Infections in Atlanta.
The child's story is different from the now famous case of Timothy Ray Brown, the so-called 'Berlin patient,' whose HIV infection was completely eradicated through an elaborate treatment for leukemia in 2007 that involved the destruction of his immune system and a stem cell transplant from a donor with a rare genetic mutation that resists HIV infection.
'We
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HIV Doctors Say Infected Baby Girl 'Cured'
A US baby girl born with HIV has been cured after very early treatment with standard drug therapy, researchers say.
The Mississippi child is now two-and-a-half years old and has been off HIV drugs for about a year with no signs of infection.
More testing needs to be done to see if the treatment would have the same effect on other children.
But the case could change the way high-risk babies are treated and possibly lead to a cure for children with HIV, which causes Aids.
'This is a proof of concept that HIV can be potentially curable in infants,' said Dr Deborah Persaud, a virologist at Johns Hopkins University in Baltimore.
She presented the findings at the conference on Retroviruses and Opportunistic Infections in Atlanta.
If the baby stays healthy, it would be only the second reported case of a person who has recovered from HIV after that of Timothy Ray Brown, known as 'Berlin patient', in 2007.
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Doctors say they have cured an infant born with HIV for the first time by giving her a cocktail of drugs shortly after birth, a result that could point the way toward saving the lives of thousands more infected children.
The baby, whose identity has been kept anonymous, began taking a regimen of AIDS drugs about 30 hours after she was born at a rural Mississippi hospital, doctors said Sunday at a medical meeting in Atlanta. At 18 months, the mother took the child off the medication. With no signs of the virus for 10 months, the infant was deemed 'functionally cured,' researchers said.
HIV treatments can hold the disease at bay, though stopping the drugs can be a death sentence since it allows infected cells secreted within the immune system to re-emerge, spreading the virus anew. Administering the mix of drugs right after birth may have stopped the virus from forming hidden reservoirs. If confirmed in further studies, the approach could help cure some of the 300,000 children infected each year with the AIDS virus.
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'Some babies here in the U.S. and Western Europe, and an awful lot of babies in the developing world don't have the opportunity for prevention,' said Hannah Gay, who treated the infant at the University of Mississippi in Jackson. 'There would be scores of babies that would benefit if we can find a strategy for interventio
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New findings could be especially critical for AIDS-plagued African countries where many babies are born with virus.
A baby girl who was born with HIV has been cured after very early treatment with standard drug therapy, US researchers have said, in a potentially groundbreaking case that could help eradicate HIV infection in its youngest victims.
Specialists made the announcement on Sunday at a major AIDS meeting in the US city of Atlanta.
'This is a proof of concept that HIV can be potentially curable in infants,' said Dr. Deborah Persaud, a virologist at Johns Hopkins University in Baltimore, who presented the findings.
The baby girl was born in a rural hospital in the state of Mississippi and her mother had just tested positive for HIV infection.
A team of doctors at the University of Mississippi Medical Centre in Jackson then put the infant on a cocktail of three standard HIV-fighting drugs when she was just 30 hours old.
That fast action apparently knocked out the HIV in the baby's blood before it could form reservoirs in the body.
The new findings could be especially critical for AIDS-plagued African countries where many babies are born with the virus, researchers said.
'You could call this about as close to a cure, if not a cure, that we've seen,'' Dr. Anthony Fauci of the National Institutes of Health, who is familia
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Baby with HIV Cured.
In the first case of its kind, medical experts in the US have made history by curing a child born with HIV - the infection that can lead to AIDS.
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A baby born with the virus that causes AIDS appears to have been cured, scientists announced Sunday, describing the case of a child from Mississippi who's now 21/4 and has been off medication for about a year with no signs of infection. (March 4)
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Details have just been released of a development in the search for an HIV cure. While experts say that's still a way off, they're encouraged by what's being described as the first functional cure of HIV in an infant. Al Jazeera's Phil Lavelle reports.
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